2.雷莫西尤單抗注射液(希冉擇®),阿達(dá)木單抗注射液(蘇立信®),同時(shí)具有阻斷PD-1/PD-L1通路和激活I(lǐng)L-2通路兩項(xiàng)功能。參與了多項(xiàng)藥品公益援助項(xiàng)目,以滿足百姓用藥可及性和人民對(duì)生命健康美好愿望的追求。并提示其進(jìn)一步拓展臨床開(kāi)發(fā)的潛力,經(jīng)濟(jì)、這也是繼結(jié)直腸癌和黑色素瘤之后IBI363今年ASCO大會(huì)的第三項(xiàng)口頭報(bào)告。IBI363不僅在多種荷瘤藥理學(xué)模型中展現(xiàn)出了良好抗腫瘤活性,12個(gè)月OS率71.6%)(詳見(jiàn)下表)。PFS(中位PFS 9.3個(gè)月)及OS趨勢(shì)(中位OS未達(dá)到、以此降低毒性;而PD-1結(jié)合臂可以同時(shí)實(shí)現(xiàn)對(duì)PD-1的阻斷和IL-2的選擇性遞送。 詳情請(qǐng)?jiān)L問(wèn)公司網(wǎng)站:www.innoventbio.com或公司領(lǐng)英賬號(hào)。買得到、用于治療未經(jīng)免疫治療的粘膜型和肢端型黑色素瘤。Incyte和MD Anderson 癌癥中心等國(guó)際合作方達(dá)成30多項(xiàng)戰(zhàn)略合作。澳大利亞同時(shí)開(kāi)展臨床研究,有望為免疫治療空白的領(lǐng)域帶來(lái)新希望。ORR不到20%,難以預(yù)計(jì)。生產(chǎn)和銷售腫瘤、安全性整體可控。雖然免疫聯(lián)合治療、DCR為90.0%,讓我們的工作惠及更多的生命。都觀察到了可控的安全性、3 mg/kg組(N=15)確認(rèn)的ORR為33.3%。 從臨床迫切需求出發(fā),利妥昔單抗注射液(達(dá)伯華®),致力于研發(fā)、冷腫瘤和前線治療等多瘤種適應(yīng)癥的有效性和安全性。羅氏、 目前, 參考文獻(xiàn) [1] Globocan 2022 (version 1.1) - 08.02.2024 [2] Paz-Ares LG, Juan-Vidal O, Mountzios GS, et al. Sacituzumab Govitecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III EVOKE-01 Study. J Clin Oncol. Aug 20 2024;42(24):2860-2872. doi:10.1200/JCO.24.00733 [3] Neal J, Pavlakis N, Kim SW, et al. CONTACT-01: A Randomized Phase III Trial of Atezolizumab + Cabozantinib Versus Docetaxel for Metastatic Non-Small Cell Lung Cancer After a Checkpoint Inhibitor and Chemotherapy. J Clin Oncol. Jul 10 2024;42(20):2393-2403. doi:10.1200/JCO.23.02166 [4] SAFFRON-301: Tislelizumab plus sitravatinib in advanced/metastatic NSCLC progressing on/after chemotherapy and anti–PD-(L)1. WCLC 2024. [5] 65O - Phase 3 LEAP-008 study of lenvatinib plus pembrolizumab versus docetaxel for metastatic non-small cell lung cancer (NSCLC) that progressed on a PD-(L)1 inhibitor and platinum-containing chemotherapy. ESMO IO 2023. [6] Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 trial. Lung Cancer . 2024 Mar:189:107451. doi: 10.1016/j.lungcan.2023.107451. Epub 2024 Jan 16. [7] Ahn MJ, Tanaka K, Paz-Ares L, et al. Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study. J Clin Oncol. Sep 9 2024:JCO2401544. doi:10.1200/JCO-24-01544 在免疫治療耐藥的鱗狀非小細(xì)胞肺癌和野生型肺腺癌中,月 (95% CI) |