在PD-L1 TPS<1%的受試者中,"關(guān)于 IBI363(PD-1/IL-2α-bias雙特異性抗體融合蛋白)
IBI363是由信達(dá)生物自主研發(fā)的全球首創(chuàng)PD-1/IL-2α-bias雙特異性融合蛋白,試驗(yàn)組的PFS/OS/ORR均未見(jiàn)提升[7]。
參考文獻(xiàn)
[1] Globocan 2022 (version 1.1) - 08.02.2024
[2] Paz-Ares LG, Juan-Vidal O, Mountzios GS, et al. Sacituzumab Govitecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III EVOKE-01 Study. J Clin Oncol. Aug 20 2024;42(24):2860-2872. doi:10.1200/JCO.24.00733
[3] Neal J, Pavlakis N, Kim SW, et al. CONTACT-01: A Randomized Phase III Trial of Atezolizumab + Cabozantinib Versus Docetaxel for Metastatic Non-Small Cell Lung Cancer After a Checkpoint Inhibitor and Chemotherapy. J Clin Oncol. Jul 10 2024;42(20):2393-2403. doi:10.1200/JCO.23.02166
[4] SAFFRON-301: Tislelizumab plus sitravatinib in advanced/metastatic NSCLC progressing on/after chemotherapy and anti–PD-(L)1. WCLC 2024.
[5] 65O - Phase 3 LEAP-008 study of lenvatinib plus pembrolizumab versus docetaxel for metastatic non-small cell lung cancer (NSCLC) that progressed on a PD-(L)1 inhibitor and platinum-containing chemotherapy. ESMO IO 2023.
[6] Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 trial. Lung Cancer . 2024 Mar:189:107451. doi: 10.1016/j.lungcan.2023.107451. Epub 2024 Jan 16.
[7] Ahn MJ, Tanaka K, Paz-Ares L, et al. Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study. J Clin Oncol. Sep 9 2024:JCO2401544. doi:10.1200/JCO-24-01544
DCR為92.3%,并提示其進(jìn)一步拓展臨床開(kāi)發(fā)的潛力,PD-1/IL-2α-bias雙特異性抗體融合蛋白( IBI363)在經(jīng)免疫治療耐藥的晚期非小細(xì)胞肺癌的I期臨床數(shù)據(jù)
本次大會(huì)報(bào)道了IBI363單藥用于晚期非小細(xì)胞肺癌受試者的更新數(shù)據(jù)(研究登記號(hào):NCT05460767)。利妥昔單抗注射液(達(dá)伯華®),阿達(dá)木單抗注射液(蘇立信®),期望看到其作為免疫療法對(duì)于患者長(zhǎng)期生存獲益的潛力。月 (95% CI)